APPLICATIONS

CryLaS laser systems are used extensively in many applications within several markets including, but not limited to, scientific research, medical/biomedical, semiconductor and industrial. Our compact, low noise lasers have excellent long-term stability, making them ideal for demanding 24/7 and volume applications. The menu below is a cross-section representation of applications in today’s markets.

Questions regarding products for applications not listed here should be directed to sales@crylas.de.

APPLICATION NOTES

Fluorescence

Laser-induced fluorescence (LIF) is a spectroscopic method in which an atom or molecule is excited to a higher energy level by the absorption of laser photons followed by spontaneous emission of photons. LIF is used for studying structure of molecules, detection of selective species and flow visualization measurements.


Fluorescence lifetime imaging microscopy (FLIM) is an imaging technique for producing an image based on the differences in the exponential decay rate of the fluorescence from a fluorescent sample. It can be used as an imaging technique in confocal microscopy, two-photon excitation microscopy, and multiphoton tomography. The lifetime of the fluorophore signal, rather than its intensity, is used to create the image in FLIM. This has the advantage of minimizing the effect of photon scattering in thick layers of sample.


Related products: FQSS266-Q, FQSS266-50, FQCW266-10-C, FTSS355-Q, FDSS532-Q


Related articles:


1. Applicability of UV laser-induced solid-state fluorescence spectroscopy for characterization of solid dosage forms, 2014

2. On-line tar characterization from pyrolysis of wood particles in a technical-scale fixed-bed reactor by applying Laser-Induced Fluorescence (LIF), 2013

3. On-line coupled capillary isotachophoresis‐capillary zone electrophoresis [...] with laser induced fluorescence detection, 2013

4. Immuno-magnetic beads-based extraction-capillary zone electrophoresis-deep UV laser-induced fluorescence analysis of erythropoietin, 2012

5. Analysis of gas-phase polycyclic aromatic hydrocarbon mixtures by laser-induced fluorescence, 2010


Photoluminescence

Photoluminescence (PL) is light emission from any form of matter after the absorption of photons. It is one of many forms of luminescence. Following excitation various relaxation processes typically occur in which other photons are re-radiated. Time periods between absorption and emission may vary: ranging from short femtosecond regime for emission involving free-carrier plasma in inorganic semiconductors up to milliseconds for phosphorescence processes in molecular systems and under special circumstances delay of emission may even span from minutes up to hours. Observation of PL at a certain energy can be viewed as an indication that an electron populated an excited state associated with this transition energy and act as sources for PL in many-body systems such as semiconductors.


Related products: FQSS266-QFQCW266-10, FQCW266-25, FQCW266-50, FQCW266-10-C, FTSS355-50, FDSS355-Q, FDSS532-Q


Related articles:


1. Investigation on interface-related defects by photoluminescence of cubic (Al)GaN/AlN multi-quantum wells structures, 2018

2. Measurement of the Emission Lifetime of a GaN Interface Fluctuation Quantum Dot by Power Dependent Single Photon Dynamics, 2018 

3. Process control of MOCVD growth for LEDs by in-situ photoluminescence, 2016

4. Photoluminescence properties of zinc white: an insight into its emission mechanisms through the study of historical artist materials, 2016

5. Transport of dipolar excitons in (Al,Ga)N/GaN quantum wells, 2015 

6. Structure and photoluminescence of the TiO2 films grown by atomic layer deposition using tetrakis-dimethylamino titanium and ozone, 2015

7. Luminescence of Eu ion in alumina prepared by plasma electrolytic oxidation, 2015

8. Analysis of cadmium-based pigments with time-resolved photoluminescence, 2014

9. Extended-Defect-Related Photoluminescence Line at 3.33 eV in Nanostructured ZnO Thin Films, 2013 

10. Photoluminescence from SiNxOy films deposited by reactive sputtering, 2013

11. Intra-center and recombination luminescence of bismuth defects in fused and unfused amorphous silica fabricated by SPCVD, 2013

12. The luminescence of ZnO ceramics, 2010


Mass Spectrometry

Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio. In simpler terms, a mass spectrum measures the masses within a sample. Mass spectrometry is used in many different fields, as in pharmacology and for protein characterisation, and is applied to pure samples as well as complex mixtures. Laser assisted creation for ions was dominated by excimer laser many decades and DPSSL show benefits for replacement.


Related products: FQSS213-Q, FQSS213-50, eMOPA213-20, FQSS266-50, FQSS266-200, FTSS355-Q


Related articles:


1. Methods of Ultraviolet Photodissociation for Mass Spectrometry, 2018

2. Directed-Backbone Dissociation Following Bond-Specific Carbon-Sulfur UVPD at 213 nm, 2018

3. MALDI MS Imaging at Acquisition Rates Exceeding 100 Pixels per Second, 2018

4. Electrospray Ionization with High-Resolution Mass Spectrometry as a Tool for Lignomics: Lignin Mass Spectrum Deconvolution, 2018

5. The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics, 2017 

6. Atmospheric pressure laser ionization with a novel highly sensitive atmospheric pressure ionization interface for gas-chromatography-mass spectrometry, 2013 

7. On the Ionization Mechanism in Negative Ion Atmospheric Pressure Mass Spectrometry and the Role of Cluster Formation, 2012 

8. Evaluation of the Performance of Small Diode Pumped UV Solid State (DPSS) Nd:YAG Lasers as New Radiation Sources for APLI-MS, 2011


Microdissection

Laser-capture microdissection (LCM) is a method to procure subpopulations of tissue cells under direct microscopic visualization. LCM technology can harvest the cells of interest directly or can isolate specific cells by cutting away unwanted cells to give histologically pure enriched cell populations. A variety of downstream applications exist: DNA genotyping and loss-of-heterozygosity (LOH) analysis, RNA transcript profiling, cDNA library generation, proteomics discovery and signal-pathway profiling.


Related products: FTSS355-50FTSS355-Q


Related articles:


1. Auxin analysis using laser microdissected plant tissues sections, 2018

2. Recommendations for mRNA analysis of micro-dissected glomerular tufts from paraffin-embedded human kidney biopsy samples, 2018

3. The combinatorial approach of laser-captured microdissection [...] accurately determines HER2 status in breast cancer, 2016

4. Laser capture microdissection in Ectocarpus siliculosus: the pathway to cell-specific transcriptomics in brown algae, 2015

5. Forced arm use is superior to voluntary training for motor recovery and brain plasticity after cortical ischemia in rats, 2014

6. Development of the Mouse Dermal Adipose Layer [...] Adipose Tissue and Is Marked by Restricted Early Expression of FABP4, 2013

7. Immuno-magnetic beads-based extraction-capillary zone electrophoresis-deep UV laser-induced fluorescence analysis of erythropoietin, 2012

8. Western blot detection of brain phosphoproteins after performing Laser Microdissection and Pressure Catapulting (LMPC), 2011

9. Analysis of gas-phase polycyclic aromatic hydrocarbon mixtures by laser-induced fluorescence, 2010


Lithography

Photolithography, also known as UV lithography (UVL), is a process used in microfabrication to pattern parts of a thin film or the bulk of a substrate. It uses photons to transfer a geometric pattern from a photomask to a light-sensitive chemical photoresist on the substrate. For example, complex integrated circuits or CMOS wafer go through several photolithographic cycles. Other techniques as laser interference lithography (LIL), nano-imprint lithography (NIL) and stereolithography (SLA) are techniques for patterning regular arrays of fine features, without the use of complex optical photomasks and 3D prototyping for medical and biotechnology applications.


Related products: FQCW266-50, FQCW266-100, FQCW266-200, FQCW266-500, FTSS355-Q, FTSS355-50


Related articles:


1. Real-Time Compensation of Simultaneous [...] Substrate Motion in Scanning Beam Laser Interference Lithography System, 2018

2. Optimized vascular network by stereolithography for tissue engineered skin, 2018

2. Single‐mode distributed feedback laser operation with no dependence on the morphology of the gain medium, 2017

3. A physically transient and eco-friendly distributed feedback laser chemosensor for detecting acid vapor, 2017

4. Low threshold simultaneous multi-wavelength amplified spontaneous emission modulated by the lithium fluoride/Ag layers, 2015

5. Utilizing laser interference lithography to fabricate hierarchical optical active nanostructures inspired by the blue Morpho butterfly, 2014

6. White organic light emitting diodes with enhanced internal and external outcoupling for ultra-efficient light extraction and Lambertian emission, 2012


Scatterometry

Scatterometers are widely used in metrology for roughness of polished and lapped surfaces in semiconductor and precision machining industries. They provide a fast and non-contact alternative to traditional stylus methods for topography assessment. Scatterometers are compatible with vacuum environment, are not sensitive to vibration, and can be readily integrated with surface processing and other metrology tools.


Related products: FQCW266-10, FQCW266-25, FQCW266-50, FQCW266-10-C


Related articles:


1. Metrology of nanoscale grating structures by UV scatterometry, 2017

2. Numerical investigations of the influence of different commonly applied approximations in scatterometry, 2013

3. First steps towards a scatterometry reference standard, 2012

4. Deep ultraviolet scatterometer for dimensional characterization of nanostructures: system improvements and test measurements, 2011

 

Engraving / Marking

Laser engraving, which is a subset of laser marking, is the practice of using laser to engrave an object. Laser marking, on the other hand, is a broader category of methods to leave marks on an object, which also includes color change due to chemical/molecular alteration, charring, foaming, melting, ablation, and more. Transparent materials as glass, polymers and gemstones can be marked with UV laser sources.


Related products: eMOPA266-40, eMOPA213-20, MOPA355-200, MOPA355-500mW, FQSS266-Q, FQSS213-Q 


Related articles:


1. Device and process for marking an ophthalmic lens with a pulsed laser of wavelength and energy selected per pulse, 2018

2. System and method for gemstone microinscription, 2006

3. Laser making system and certificate for a gemstone, 1996